Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

The cellular function of active DNA demethylation in neurons is not well understood. Here, Song and colleagues show that synaptic activity modulates Tet3 signaling, which in turn regulates glutamatergic synaptic transmission and synaptic scaling. Their work identifies Tet3 as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-plasticity of neurons via active DNA demethylation.