Automated, High-Throughput, Multi-scale Assessment of Bone Morphology and Bone Competence

Osteoporosis, the most prevalent degenerative disease in western societies, is characterized by a reduction in bone mass and altered architectural arrangement of bone tissue; however, how bone morphology on different length scales contributes to overall bone strength and how mechanical stresses are translated into biochemical signals is still poorly understood. This study aims to establish a framework for the automated high-throughput assessment of bone morphology and bone competence on length scales ranging from cellular to organ.