Synthesis, structure, spectral characterization, electrochemistry and evaluation of antibacterial potentiality of a novel oxime-based palladium(II) compound.

Abstract The title monomeric Pd(II) compound, [Pd(L)(Cl)], was synthesized in moderate yield out of the reaction of equimolar proportion of Na 2 [PdCl 4 ] and 3-[(5-bromo-2-hydroxy-benzylidene)-hydrazono]-butan-2-one oxime ( LH ) in tetrahydrofuran milieu. LH is a 1:1 Schiff-base condensate of 2,3-butanedionemonoxime monohydrazone and 5-bromosalicylaldehyde. [Pd(L)(Cl)] has been characterized by C, H and N microanalyses, 1 H and 13 C NMR, FAB-MS, FT-IR, Raman spectra, UV–Vis spectra and molar electrical conductivity measurements. [Pd(L)(Cl)] is diamagnetic. Structural elucidation reveals that the palladium center in [Pd(L)(Cl)] is nested in ‘N 2 OCl’ coordination environment. The geometry around Pd in [Pd(L)(Cl)] is distorted square-planar. The redox behavior of [Pd(L)(Cl)] in DMF shows a reduction couple, Pd(II)/Pd(I) at −0.836 V versus Ag/AgCl. The in vitro antimicrobial activity of [Pd(L)(Cl)] was screened against both Gram-positive and Gram-negative human pathogenic bacteria. This bioactivity was substantiated with SEM study. [Pd(L)(Cl)] exhibits satisfactory bactericidal as well as bacteriostatic activity.