The influence of Roux-en-Y gastric bypass surgery on inflammatory markers and pulmonary function amelioration

Abstract Objective Roux-en-Y gastric bypass surgery is currently considered the most effective weight loss tool, which results in reduction of inflammation, control of metabolic syndrome and improvement of respiratory function performance and of quality of life. We aimed to analyze pulmonary function, inflammatory markers and anthropometric measurements in subjects with obesity submitted to Roux-en-Y gastric bypass surgery, and to verify the existence of a correlation between inflammatory markers and respiratory function at respective moments. Material and Methods A sample composed of 35 adults with obesity underwent analysis of inflammatory markers and venous blood gases, pulmonary function testing and anthropometric measurements in the preoperative period and six months after surgery. Results A substantial reduction was observed between anthropometric measurements after surgical intervention; a substantial improvement in inflammatory markers, Cholesterol, Creatinine, Total Protein, Triglycerides, Uric Acid, C-Reactive Protein, LDL and VLDL, as well as an improved performance in the pulmonary function test analyzed after surgical intervention. In the postoperative period, only a correlation between Vitamin D and the FEV 1 /FVC ratio was detected. Conclusion Bariatric surgery results in weight reduction, improvement of metabolic and inflammatory parameters and in the present day has an important role in reducing the morbimortality associated with obesity.