АНТИДИАБЕТИЧЕСКИЕ СВОЙСТВА БЕНЗОФУРОКАИНА И ВЛИЯНИЕ ЕГО НА ЭНДОТЕЛИАЛЬНУЮ ДИСФУНКЦИЮ И К + -КАНАЛОПАТИЮ АОРТЫ В ЭКСПЕРИМЕНТЕ

Experiments on rats have proved that under the conditions of experimental diabetes mellitus benzofurocainum manifests mild anesthetic and cardiotropic (antiarrhythmic and antianginal) activity as well as marked antiinfl ammatory (without ulcer genic side effect) and healing properties alongside the hypoglycemic effect in the early stages of diabetes mellitus (within 30 days). The trend to restoration of the endothelium-dependent dilatation of smooth aorta cells has been observed at that. Benzofurocainum infl uences neither these characteristics in the late stages of diabetes mellitus (within 90 days); nor the K + -canals functioning of smooth aorta cells in both stages of research. It has been assumed that the hypoglycemic effect of benzofurocainum might be attributed to its antioxidative, antihypoxic and anti-infl ammatory properties as well as to its ability to stimulate the activity of NADand NADF-dependent dehydrogenases in s-cells of the Sobolev-Langerhans islets of the pancreas.