IL-1B rs16944 polymorphism is related to septic shock and death

Background IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyze whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. Methods We performed a case-control study on 467 patients who underwent major cardiac or abdominal surgery. Out of them, 205 patients developed septic shock (Cases, SS-group) and 262 patients developed SIRS (Controls, SIRS-group). The primary outcome variables were the development of septic shock and death within 90 days after diagnosis of septic shock. The IL-1B rs16944 polymorphism was genotyped by Sequenom's MassARRAY platform. The association analysis was performed under a recessive genetic model (AA vs. GG/GC). Results The frequency of septic shock was higher in patients with IL-1B rs16944 AA genotype than in patients with IL-1B rs16944 GG/AG genotype when all patients were taken into account (63.6% vs 41.8%; p=0.006), cardiac surgery (52.2% vs. 33.3%; p=0.072), and abdominal surgery (76.2% vs. 50.2%; p=0.023). However, the IL-1B rs16944 AA genotype was only associated with higher likelihood of septic shock in the analysis all population [adjusted odds ratio (aOR)=2.26 (95%CI=1.03; 4.97; p=0.042], but not when it was stratified by cardiac surgery (p=0.175) or abdominal surgery (p=0.467). Similarly, IL-1B rs16944 AA genotype was also associated with higher likelihood of septic shock-related death in all population [aOR=2.67 (95%CI=1.07; 4.97); p=0.035]. Conclusions IL-1B rs16944 AA genotype seems to be related to the onset of septic shock and death in patients who underwent major surgery. This article is protected by copyright. All rights reserved.