GnRH antagonists for treatment of polycystic ovarian syndrome

Abstract Objective To review treatment options for women with polycystic ovary syndrome (PCOS) seeking relief from infertility. Design Review article and case studies. Results Treatment options for women with PCOS include lifestyle modification, treatment with insulin-sensitizing agents, ovulation induction with clomiphene citrate (CC), FSH preparations, and possibly, GnRH antagonists. Conclusions The GnRH antagonists provide a new treatment option for women with PCOS. When the goal is to restore normal ovulation, the use of GnRH antagonists is limited to the prevention of LH surges. When undertaking controlled ovarian hyperstimulation (COH) in women with PCOS, a GnRH antagonist protocol should be the protocol of choice.