Factors predicting clinical outcomes from 494 oocyte vitrification and donation cycles and 705 subsequent recipient embryo transfers at a UK-regulated egg bank

Abstract Research question Do donor age, AMH, AFC, BMI and reproductive history predict response to ovarian stimulation? Do donor and recipient clinical markers and embryology parameters predict recipient pregnancy and live birth? Design Retrospective cohort study of 494 altruistic oocyte donors aged 18–35 years; 340 were matched to 559 recipients. Predictors of donor total oocyte yield and total mature oocyte yield were identified. Total and mature oocyte number were compared according to stratified donor AMH and age. Donor, recipient and embryology parameters predictive of recipient primary outcomes (clinical pregnancy and live birth) were identified. Results Donor age and AMH predicted total oocyte yield (P = 0.030 and P Conclusions Donor age and AMH are independent predictors of oocyte yield. Raised recipient BMI and history of miscarriages reduce cumulative live birth rates, which may be increased by selecting donors aged 23–29 years, instead of younger donors.