Acute Dermal Irritation Study of JP-8 and S-8 in New Zealand White Rabbits

Abstract : The objective of this study was to determine the irritative potential of JP-8, S-8 and a 50/50 volume/volume mixture of JP-8 and S-8 following a single exposure to the skin of albino rabbits. Three groups of three albino rabbits received a single, four-hour, occluded exposure and an additional three groups received a single, four-hour, semi-occluded exposure. Doses (0.5 mL) of the test substances were applied to clipped, unabraded skin. At the completion of all exposures, the bandages were removed and the sites washed. Application sites were evaluated at approximately 30 to 60 minutes; 24, 48 and 72 hours; and 4, 7 and 14 days after patch removal for sites where irritation persisted. Occluded exposures of JP-8 or S-8 resulted in a classification of moderately irritating. Semi-occlusion of either JP-8 or S-8 produced slight irritation. The mixture, however, was slightly irritating in both the occluded and semi-occluded exposures.