In Vitro antibacterial activity of Ta2O5 doped glass-ceramics against pathogenic bacteria

Abstract The use of synthetic implants for restoration of damaged or diseased bone is associated with risk of bacterial colonization that result in failure of the implant. It is essential for implants to make bond with bone and soft tissue without bacterial infection. The present study is based on evaluation of the antibacterial property of Ta 2 O 5 doped novel glass ceramics having a chemical composition (40-x) SiO 2 -24.4Na 2 O-26.9 CaO-6.1CaF 2 -2.6P 2 O 5 -xTa 2 O 5 where x = 0, 0.1, 0.5, 1 and 3 mol %. In Vitro antibacterial assays were performed in dark against six common pathogenic bacterial strains; Strep. pyogenes, B. subtilis, Staph. epidermidis, E. coli , Proteus. mirabilis and Pseudomonas. aeruginosa using modified Kirby Bauer method. It was observed that all samples doped with Ta 2 O 5 showed statistically significant (P  2 O 5 demonstrated strongest antibacterial effect, which may be attributed to high concentration of Ta +5 ions observed in the supernatant (SBF). The antibacterial activity of Ta 2 O 5 doped Glass ceramics was prone to initial leaching of high ionic strength Ta +5 ions from the specimen surface to supernatant that exerts hyper-osmotic environment which inhibited bacteria. Therefore, it can be concluded that addition of Ta 2 O 5 to Glass ceramics exerted antibacterial ability to bioactive Glass ceramics composition.