Effects of sesame seed supplementation on clinical signs and symptoms in patients with knee osteoarthritis.

Aim Up to now there have been no human studies to evaluate the effect of sesame (Sesamum indicum L.) in osteoarthritis patients; this study was designed to assess the effect of administration of sesame on clinical signs and symptoms in patients with knee osteoarthritis (OA). Methods Fifty patients with knee OA referred to the only specialty and subspecialty orthopedic centers in the north-west of Iran, were selected and divided into two groups, namely control and sesame groups. Twenty-five patients in the control group received standard treatment while 25 patients in the sesame group received 40 g/day sesame by oral administration during 2 months of the study along with standard drug therapy. The KOOS Questionnaire, Timed Up and Go (TUG) and Visual Analog Scale (VAS) tests were used for clinical assessments. Results There was significant difference in pain intensity between the two groups (P = 0.004) after treatment. The mean score of the KOOS Questionnaire in both treatment and control groups was significantly increased (P = 0.001 and P = 0.001, respectively) compared with baseline. The mean score of the TUG Questionnaire in both treatment and control groups was significantly decreased (P = 0.001 and P = 0.001, respectively) compared with baseline. There was significant difference in post-treatment scores of the KOOS Questionnaire (P = 0.009) and TUG (P = 0.002) between the two groups. Conclusions The present study showed a positive effect of sesame in improving clinical signs and symptoms in patients with knee OA and indicated the fact that sesame might be a viable adjunctive therapy in treating OA.