Ocular lymphoblastic crisis in chronic myelogeneous leukemia

A patient who was known to have chronic myeloid leukemia (CML) in total systemic remission presented with bilateral pseudohypopyon and exudative retinal detachment. Anterior chamber fluid cytology revealed numerous lymphoblasts. Because peripheral blood and bone marrow profiles were normal, a diagnosis of localized lymphoblastic crisis was established. The possibility of lymphoblastic transformation in a uveal extramedullary hematopoietic focus is confronted by the theory of lymphoblastic transformation of uveal leukemic infiltrates that serve as a tumor rest untouched by the original chemotherapy.