Antibody dependent cell-mediated cytotoxicity in infants with cows milk protein intolerance and coeliac disease

ADCC (antibody dependent cell-mediated cytotoxicity) is an immune mechanism, which may participate in host defense as well as in immunopathological phenomena in the gastrointestinal tract. ADCC is usually mediated via IgG-antibodies and the K subset of mononuclear cells. Besides, an ADCC-reaction against bacteria mediated through secretory IgA-antibodies and intestinal lymphoid cells has been demonstrated (1).