P206 Factors associated with survival differences in immigrant Asians versus USA-born Asians with uterine cancer

Background We compared clinicopathological characteristics and survival outcomes in immigrant Asians versus USA-born Asians with endometrial cancer. Methods Data from 2001 through 2009 were abstracted from the Surveillance, Epidemiology, and End Results Program (SEER) database. Chi-squared, Kaplan–Meier estimates, and Cox proportional hazards regression methods were used for statistical analyses. Findings Of 4834 Asians with endometrial cancer, 1860 (38%) were immigrants from Asian countries. The median age was 56 years (range 19–96). Of the immigrants, 51% ( n  = 953) were from the Philippines and Pacific Islands, 19% (350) from China, 13% (235) from southeast Asia, 6% (117) from India, 6% (102) from Korea, and 5% (97) from Japan. In the overall study group, 16% had high disease stage and 21% had high disease grade. 3767 (78%) of patients had endometrioid, 93 (2%) had clear cell, and 285 (6%) had papillary serous histology. Compared with those born in the USA, immigrant Asians were more likely to have higher stage (33% versus 28%, p p p p p p  = 0.10). On multivariate analysis, age (hazard ratio [HR] 1.05, confidence interval [CI] 1.04–1.06, p p p Interpretation Immigrant Asians with endometrial cancer have poorer survival compared with their US-born counterparts. This may be attributed to a higher proportion of advanced stage, poor histologic subtypes, and higher grade of disease.