Comparative study of the immunogenicity of various forms of Naja oxiana cardiotoxin

: Comparative study of the immune sera from rabbits immunized with both formol and native cardiotoxins, cardiotoxin incorporated into sphingomyelin-phosphatidylcholine-cholesterol liposome stabilized with osmium tetroxide, and a cardiotoxin-succinylated bovine albumin conjugate was performed. The latter produced antibodies identified by immunodiffusion assay. The highest survival was observed in animals treated with antiserum to cardiotoxin-albumin conjugate, followed by antitoxin to combination of formol and native cardiotoxins. Antiserum to cardiotoxin in liposome was ineffective.