Morphological and biochemical changes in the connective tissue in chronic chloroacetophone poisoning

: The qualitative and quantitative characteristic of the connective tissue of aorta of albino rats was followed up, the rats having been treated with phosphororganic pesticide chloracetophon in doses I/20 and I/100 LD50 for six months. With the effect of the lower dose, disturbances were observed, affecting mainly the components of the main intercellular substance--glycoproteins and glycosaminoglycans. The higher dose leads to disturbances in the quality and quantity of the fibrous structures--elastin and collagen on the background of changed ratio sulphated GAG/non-sulphated GAG. The changes observed are an evidence for an accelerated ageing of the vascular aortic wall under the effect of chloracetophon and should be given consideration for its hygienic standardization.