SENP1 severs a vital function in human glioma cells

Objective To investigate the role of sentrin/SUMO-specific protease 1 (SENP1) plays in human glioma cells by knockdown SENP1 with adenovirus transfection.Methods To knockdown SENP1,sh-SENP1 adenovirus were transfected into glioma cells LN229.The relative cell viability and apoptosis in glioma cells were observed to define the effect of SENP1 down-regulation on cell proliferation and apoptosis.And the effect of SENP1 down-regulation on cell migration was detected by a transwell migration system.Results SENP1 knockdown inhibited cell proliferation and induced apoptosis in human glioma cells.Further,we found that SENP1 knockdown obviously suppressed tumor cell migration.Conclusions These results demonstrate that SENP1 plays a critical role in human glioma cells. Key words: Glioma ;  Mastadenovirus ;  Apoptosis