Impact of different gonadotropin and GnRH agonist regimens on serum and follicular fluid hormone levels and folliculogenesis

Gonadotropin-releasing hormone agonists (GnRH-a) are currently used in virtually every assisted reproduction ovulation induction cycle to reduce cancellation rates and to improve treatment outcome. The combination of GnRH-a and gonadotropins appears to be safe and devoid of direct side-effects even when GnRH-a are administered in early pregnancy. We recently showed that long GnRH-a regimens are preferable to short (flare-up) regimens as they result in a greater follicle yield and a better intrafollicular endocrine environment. Thus, the combined use of long GnRH-a regimens and gonadotropins for assisted reproduction ovulation induction is destined to further grow.