[Effects of Shengmai injection on testicular injury after torsion/detorsion in rats of different ages].

Objective:To investigate the different effects of Shengmai injection on testicular injury after testis torsion/detorsion in rats of different ages.Methods: Sixteen healthy male SD rats aged 3,6 and 12 weeks were equally randomized into an experimental group (testicular torsion/detorsion plus Shengmai injection) and a control group (testicular torsion/detorsion plus saline).The rat models of testicular torsion were killed 24 h after surgery for the measurement of total antioxidant capacity (T-AOC),superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the testis.Results: Compared with the controls,the 3-and 6-week-old rats of the experimental group showed no significant changes in T-AOC,SOD activity and MDA content (P 0.05),while the 12-week-old experimental rats exhibited a remarkable increase in SOD and T-AOC and an obvious decrease in MDA content (P 0.05).Conclusion: Shengmai injection has a protective effect against acute ischemia-reperfusion testicular injury after torsion/detorsion in rats,but the effect varies with the age,more obvious in older ones.