Tumour Localization of Boronated Porphyrins in an Intracerebral Model of Glioma

Treatment of the most common cerebral tumour, cerebral glioma, is unsatisfactory as the tumour recurs due to inadequate local control (1). Photodynamic therapy (PDT) and Boron Neutron Capture Therapy (BNCT) offer some promise as adjuvant treatments for cerebral glioma. Several clinical trials have been reported utilizing PDT (for review see reference 1) and BNCT (2) to treat the high grade glioma, glioblastoma multiforme. We have investigated the pharmacokinetic tissue distribution of the photosensitizer Haematoporphyrin derivative (HpD), the nido carboranyl porphyrin, boron tetraphenyl porphine (BTPP) and the closo carboranyl monomeric protoporphyrin (BOPP) in CBA mice bearing the intracerebral C6 glioma xenograft (3).