Memantine hydrochloride oral solid tablet preparation method and obtained product

The invention discloses a memantine hydrochloride oral solid tablet preparation method and an obtained product. The preparation method comprises the following steps: A, mixing and sieving memantine hydrochloride with a hydrophilic auxiliary material; B, sieving other auxiliary materials; C, putting the mixture of the step A and the mixture of the step B in a three-dimensional mixer, and totally mixing, wherein the three-dimensional mixer rotation speed is 5-20 rpm and the time is 5-20 min; D, tabeltting the mixed powder of the step C with a heterotypic punching die having the middle with nicks and a high-speed tablet press having a pre-pressing function, and adjusting the hardness pressure of the tablet to be 60 N-100 N. The memantine hydrochloride solid tablet adopts the powder direct tabletting preparation method; the preparation method is simple and controllable in process and easy to operate, avoids tedious drug pre-treatment procedures, is suitable for industrialized production, and reduces the cost effectively. The product keeps crystal form states of memantine hydrochloride main drug ingredients, has good compressibility, and is easily made into the tablet.