FRI0059 Interstitial lung disease in patients with rheumatoid arthritis of a cohort treated with methotrexate monotherapy

Background Diffuse interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and an important cause of morbidity and mortality in this patient population. The predisposing and prognostic factors of this complication are a matter of debate. Objectives To determine the characteristics associated with the development of ILD in a cohort of patients with RA who received Methotrexate (MTX) monotherapy. Methods Case-control study in a cohort of patients with RA who had received MTX monotherapy, being cases those who developed ILD and controls, those who did not develop it. Results The cohort consisted of 301 patients (67% women), with a mean age of 49.6 (±13.2) years and a follow-up of 135.8 (±93.5) months. There were 15 (5%) cases of ILD, classified by high resolution chest CT as usual interstitial pneumonitis 7, nonspecific interstitial pneumonitis 7 and interstitial bronchiolitis 1. The distribution by sex was 8 ILD among 202 women (3.9%) and 7 ILD among the 99 men (7.1%). They all had RF and/or ACPA positive. ILD was associated with longer duration of the disease (p Conclusions ILD is a frequent and serious complication in RA. It appears more frequently in patients with previous pneumopathy and long-term disease and with extra-articular involvement of RA. Disclosure of Interest None declared