Functional Immune Reconstitution by Interleukin-2 Adjunctive Therapy for HIV/Mycobacterial Co-infection

To the Editor: We describe a case of an immunocompromised patient with AIDS who sought treatment for immunotolerance to an invasive, systemic mycobacterial infection that was unresponsive to antimycobacterial therapy alone. The 41-year old man sought treatment in November 2006 for fatigue, dyspnea, and epigastric pain of 4 weeks’ duration and weight loss of 10 kg. HIV-1 infection (20 cells/μL CD4+ T-cells, viral load 230,000 genome equivalents/mL) was diagnosed. Antiretroviral therapy (ART) and Pneumocystis pneumonia prophylaxis were initiated.