Rapid Oral Desensitisation To Isoniazide

Tuberculosis remains the leading cause of death world-wide from any infectious agent and the alarming increase in the annual incidence of new cases has been described as a global emergency with figures of 10 million infected and 3.5 million deaths projected for the year 2005 (1). Adverse reactions to anti-tuberculosis drugs occur in about 5% of treated patients and can be responsible for cessation or switching the therapy(2,3). This is of particularly concern in systemic disease, in which allergic reactions to Isoniazide (INZ) make desensitisation necessary. We present a case report of rapid oral desensitisation to Isoniazide