Expedient one-pot synthesis of pyrroles from ketones, hydroxylamine, and 1,2-dichloroethane

Abstract 2- and 2,3-Substituted pyrroles are readily synthesized in a one-pot procedure from ketones, hydroxylamine hydrochloride, and 1,2-dichloroethane in the KOH/DMSO system (120 °C, 2–4 h), the yields of pyrroles ranging 11–85%. Aliphatic, cycloaliphatic, aromatic, and heteroaromatic ketones tolerate the reaction conditions.