Effect of side-chain length on solute encapsulation by amphiphilic heterografted brush copolymers

Anisotropic nanomaterials are non-spherical structures that possess unique shape-dependent physicochemical properties and functionalities. Inspired by the abundance of filamentous entities in nature, cylindrical nanostructures have gained significant attention due to their unique performance. Herein, we discuss the effect of side-chain length on the encapsulation properties of amphiphilic heterografted bottlebrushes. We observed that by grafting a long hydrophilic block to the double-brush, we were able to restrict solute-induced conformational changes, thus producing drug-loaded anisotropic carriers. Unimolecular encapsulation in brushes was solute-dependent as shown here for probucol and rose bengal lactone. Stabilization with an amphiphilic diblock copolymer —consisting of the same type of blocks as those comprising the heterografted brush— served to explain the solute-dependent behavior observed for brushes, suggesting that solutes with a higher propensity to nucleation could be more effectively stabilized by the anisotropic carrier in a unimolecular worm-like construct.