Aspectos farmacocinéticos del fluconazol

Fungal infections of skin and mucous membranes, as well as systemic, are now a public health problem in developed countries. The growing number of these infections and resistance to conventional treatments, among other factors, have resulted in the continuing evolution of antifungal agents, since the middle of last century to date. In 1990 were introduced triazoles, fluconazole specifically. The aim of this study was to review some aspects of this antifungal agent pharmacokinetic: mechanism of action, drug interactions, biological activity, routes of administration and hepatotoxic effects in children.