Organocatalytic Asymmetric Reaction of Indol-2-yl Carbinols with Enamides: Synthesis of Chiral 2-Indole-Substituted 1,1-Diarylalkanes.

The chiral phosphoramide-catalyzed asymmetric reaction of indol-2-yl carbinols with enamides is presented. The method provided an efficient and novel way for the synthesis of chiral 2-indole-substituted 1,1-diarylalkane derivatives.