Single-subject assessment of the distribution of white matter abnormalities measured by diffusion tensor imaging in patients with severe traumatic brain injury

Traumatic axonal injury (TAI) is a major contributor to adverse outcomes following traumatic brain injury (TBI). Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique, which provides a robust measure of white matter integrity in patients with TBI. Certain brain regions have been identified as particularly susceptible to TAI by means of DTI. Few studies, however, have focused on describing the distribution of DTI abnormalities in individual TBI patients. The aim of this project was to conduct an exploratory analysis of the extent and distribution of axonal injury in TBI patients at a singlesubject level.