In Vitro Antidiabetic Propensities, Phytochemical analysis and Mechanism of Action of Commercial Antidiabetic polyherbal formulation “Mehon”

Present investigation assessed the hypoglycemic potential of hydro-alcoholic (HAE) and aqueous (AQE) extracts of Mehon, a commercial antidiabetic polyherbal formulation using various in vitro techniques. HAE and AQE were analyzed for α-amylase and α-glucosidase inhibition, glucose adsorption, diffusion, and transport across yeast cells membrane. HAE showed higher α-glucosidase (IC50:156.95 μg/mL) inhibition. Glucose adsorption increased with increment in glucose concentration (5–100 mM/L). The rate of glucose uptake into yeast cells was linear. Both extracts exhibited time-dependent glucose diffusion. Calculated GDRI was 27.44 % (HAE) and 17.43 % (AQE) at 30 min, which reduced over time, thereby confirming the antihyperglycemic propensities of Mehon.