Evaluation of Local Side Effects of Captopril Gel in the Rabbit Model

Abstract Shirazi, M., Hassanpour, A., Khezri, A., Samani, S.M., Monabbati, A., Tanideh, N., Bahri, M.A. and Mehrabani, D. 2007. Evaluation of local side effects of captopril gel in the rabbit model. J. Appl. Anim. Res., 31: 197–199. To evaluate the safety of using captopril gel as an antifibrotic agent for preventing recurrence of urethral stricture after a direct vision internal urethrotomy, twelve rabbits were divided into three equal groups, and three types of gel were instilled into the urethra using a lubricating gel as placebo (group I), 0.1% captopril gel (group II), and 2.5% captopril gel (group III). One more rabbit served as control. Changes in the urethral mucosa were evaluated at the end of one week and three months. Mild ulceration and denudation of proximal and distal urothelium were seen with secondary aggregation of inflammatory cells beneath the lamina propria in the early phase in all three groups. No inflammation, scarring, or other side effects were seen in the late phase. As the local...