Antioxidant and inflammatory biomarkers for the identification of prodromal Parkinson's disease

Abstract Objectives We explored the role of oxidative stress and inflammatory molecules as potential Parkinson (PD) biomarkers and correlated biological with non-motor abnormalities (olfactory impairment and dysautonomia), in patients with idiopathic REM behavior disorder (iRBD) (prodromal PD) and established PD. Methods We recruited 11 iRBD and 15 patients with idiopathic PD (HohenY 95%CI 0.988–1.000) were independently associated to PD. TOS correlated with Br-GSH ( R =0.34, p=0.037), VM ratio ( R =0.43, p=0.015), and neopterin (rho=0.39, p=0.016). Conclusions Reduced systemic antioxidant capacity is found in prodromal and overt PD and may represent, in association with olfactory loss and cardiovascular dysautonomia, a useful biomarker for an integrative, early diagnosis of PD.