Hierarchy of mono- and bi-allelic TP53 alterations in Multiple Myeloma cell fitness

TO THE EDITOR: Recently, biallelic (“double hit”) TP53 inactivation, occurring in 2% to 4% of newly diagnosed multiple myeloma (MM) patients, was identified as an ultimate high-risk feature of MM, being associated with median survival of <2 years.[1][1][⇓][2]-[3][3] We and others have shown