Arginine Vasopressin(4-8) Mobilizes Intracellular Calcium in C6 Glioma Cells.

To understand the mechanism of neurotrophic action of neuropeptide Z NC(C)PR, which could affect growth of C6 cells, fluorescent dye Fluo3 and conf ocal laser scanning microscope were used to assay the intracellular cal cium in C6 glioma cells. It was found that ZNC(C)PR and it's analogue NLPR could mobilize intracellular calcium in a dose-dependent manner. The ZNC(C)PR antagonist, ZDC( C)PR, could inhibit the process, and the extracellular calcium did not influence it.