Тримебутин в лечении синдрома раздраженного кишечника и других функциональных гастроинтестинальных расстройств

Irritable bowel syndrome is seen as a «reference» for understanding pathogenetic essence of functional gastrointestinal disorders. At the basis of functional gastrointestinal disorders are combined morphological and physiological abnormalities associated with visceral hypersensitivity, impaired gastrointestinal motility, the protective mucosal barrier, immune function and composition of the intestinal microbiota, as well as disorders of the central nervous system. An important problem is the optimization of drug therapy in the treatment strategy implying functional gastrointestinal disorders priority to the use of drugs that have a multipurpose effect, simultaneously affecting several pathogenetic links of these diseases, or have a beneficial effect in the presence of comorbid pathology. This review considered trimebutine possibilities for the treatment of functional gastrointestinal disorders.