Subcutaneous continuous glucose monitoring system in assessment of a dynamics of the glycemia during and after physical activity in patients with diabetes

Our study was designed to determine serum PAPP-A and MMP-9 after renal transplantation (RTx) and to correlate them with renal function. Methods: Serum PAPP-A and MMP-9 were determined at 0, 6, and 12 months post-RTx in 80 pts 49/31 M/F, age 48.7 (22–76) years and in 22 healthy controls 10/12 M/F, age 51.0 (22–76) years. Renal function was determined as inulin clearance, and serum PAPP-A and MMP-9 by ELISA. Results: Serum PAPP-A was significantly increased at time 0 post-RTx compared with controls (24.4 12.1 vs. 9.6 1.7 mlU/l; p 0.01) and we noted a significant inverse correlation between inulin clearance and serum PAPP-A (r 0.569; p 0.01). Serum MMP-9 was significantly raised at 1 year post-RTx as against controls: median 602 vs. 355 ng/ml; p 0.01. The correlation between increased MMP-9 levels and renal function was not significant. Conclusion: The serum levels of PAPP-A are the highest prior to RTx, and their decline correlates with developing graft function. In contrast, serum MMP-9 increases in the late post-RTx period; further research is needed to explain its rise, not due to a change in renal function. Supported by grant NR/9398-3 IGA MH Czech Republic.