Comparison of the Performances of 18F-FDG PET and 11C-DPA713 PET in Patients with Symptomatic Focal Epilepsy.

1070 Purpose: To compare the performances of 18F-FDG and 11C-DPA713 using PET in patients with symptomatic focal epilepsy. Methods: Patients with symptomatic focal epilepsy are included; who were more than one year old, had not received immunosuppressants or steroids treatment, and underwent epilepsy surgery with symptoms improved. Brain MRI, FDG PET and DPA713 PET were obtained and analyzed by means of PMOD software. Volumes of interest were set to surgical sites manually. Mean standard uptake values (SUVmean) of FDG and DPA713 were obtained and asymmetry index (AI) were calculated. N30R83 Maximum Probability Atlas was used to evaluate uptake in regions excluded surgical sites and averages of |AI| were obtained, which were compared between FDG and DPA713 PET. The AI of surgical sites / the average of |AI| (the lesion-to-normal ratio of AI) were also compared. Results: Seven patients were included; seizure improvement or seizure frequency reduction was observed. Visually, the abnormal high uptakes of DPA713 were clear in good agreement with surgical sites while the abnormal low uptakes of FDG were unclear. SUVmean of DPA713 in lesion was higher than contralateral (7/7), and SUVmean of FDG was lower (5/7) and higher than contralateral (2/7). The AI of lesion was 0.17 ± 0.12 (median 0.17) for DPA713 and 0.10 ± 0.24 (median 0.05) for FDG. Also, the lesion-to-normal ratio of AI for DPA713 tended to be higher than for FDG with no significant difference. The AI of normal regions for DPA713 was significantly lower than for FDG (p <0.05), which probably make it easier to evaluate uptake of DPA713 in epileptic lesion than FDG. Conclusions: FDG and DPA713 uptakes were compared in patients with localization-related epilepsy. It was suggested that DPA713 may be more useful than FDG.