Comparison of Pencil Beam Scanning Proton- and Photon-Based Techniques for Carcinoma of the Parotid

Abstract Purpose: To report the dosimetric advantages of a comparison between pencil beam scanning (PBS) proton therapy versus intensity-modulated radiation therapy (IMRT) for parotid gland cancers. Patients and Methods: This was a retrospective, dosimetric comparison of 8 patients who received external beam radiation therapy at our institution between 2009 and 2011. Two separate plans were generated for each patient: 1 IMRT and 1 PBS plan. The prescription dose for each plan was 60 Gy for IMRT and 60 Gy (RBE) for PBS. We measured dose-volume relationships for target volumes and organs at risk with each treatment technique. Dosimetric comparisons for each organ at risk were made by using the Wilcoxon signed rank test. All tests were 2-tailed, with P values < .05 considered statistically significant. Results: The mean patient planning target volume was 160.9 cm3 (SD 74.6). Pencil beam scanning, compared to IMRT, significantly reduced the mean dose to the following structures: ipsilateral temporal lobe (2.8...