[Relations of acid-base balance and gastric secretion of hydrogen carbonate ions in patients with peptic ulcer].

AIM: To study acid-base balance (ABB) of the organism, gastric secretion of hydrocarbonate (HCO3-) in ulcer patients and to examine their relationships. MATERIAL AND METHODS: ABB in capillary or venous blood before and after losec and famotidine treatment and gastric secretion of HCO3- were studied in 72 patients with ulcer. RESULTS: It was found that patients with gastroduodenal ulcer have metabolic, less frequently hypercapnic acidosis with suppressed gastric secretion of HCO3-. This entails abnormal neutralization of the hydrochloric acid imitating high acidity of the gastric juice. HCO3- secretion is inversely proportional to pH. H2-blockers normalize ABB in ulcer patients while losec either stimulates acidosis or transforms one kind of acidosis into another. CONCLUSION: ABB and gastric secretion of HCO3- are related. Acidosis in ulcer patients leads to reduction of HCO3- production and intensification of hydrochloric acid secretion.