TREG-cell therapies for autoimmune rheumatic diseases

Regulatory T (TREG) cells can be subdivided into functional subsets. In this Review the authors apply advances in our understanding of mouse and human TREG-cell biology to outline methods for TREG-cell expansion and regulation. These techniques, which include antigen-specific expansion in vitro and in vivo, could soon be used to treat patients with autoimmune rheumatic diseases.