SY13-4FETAL ALCOHOL EXPOSURE INDUCES A LONG-TERM ALTERATION OF NMDA-DEPENDENT SYNAPTIC PLASTICITY, LEADING TO AN ABERRANT LONG TERM DEPRESSION

Ethanol exposure during fetal life can induce irreversible cognitive deficits. These deficits have been ascribed so far to a lower NMDA-dependent synaptic long-term potentiation (LTP) in the hippocampus and whether NMDA-dependent long-term depression (LTD) may also play a critical role in those deficits remained unknown. In the present study we …