382-P: Exhaled Isoprene Products Change during Hypoglycemia in Type 1 Diabetes and Home Breath Capture Is Feasible as a Diagnostic Tool

Detection of hypoglycemia is important to reduce risk and optimize glucose in T1D. Noninvasive glucose detection methods have not been fully explored. Exhaled breath isoprene, a component of sterol metabolism, has been associated with hypoglycemia in controlled studies in a limited population in the laboratory setting. Home-monitoring of breath isoprene levels may permit noninvasive hypoglycemia detection. We conducted an exploratory study measuring exhaled volatile organic compounds (VOCs) in breath samples collected during hypoglycemia (CBG Disclosure E.A. Los: Advisory Panel; Self; Medtronic. W.L. Stone: None. G. Ford: None. Funding East Tennessee State University (18-025M)