Clinical and laboratory profile of people living with HIV/AIDS with oral Kaposi sarcoma.

Objective The aim of this paper was to evaluate the clinical and laboratory profile of people with oral Kaposi's sarcoma (KS) associated with AIDS (KS-AIDS), followed up at a public university hospital in Salvador, Bahia, Brazil, in the last 10 years. Study design We identified patients diagnosed with KS-AIDS, presenting oral manifestation from January 2007 to December 2017. We searched, in the hospital information systems, the patient demographics, diagnostic data, treatment, image studies and oral photographic records. Results Of the 39 cases of KS-AIDS identified at the institution, 14 (22.8%) presented oral lesions. There was a predominance of black men, with a mean age of 32.5 years. Most cases (85.1%) manifested signs of KS simultaneously with the diagnosis of HIV infection, with extremely low initial CD4+ counts (average of 52.6 cells / mm²) and visceral involvement (64.3%). The palate (32.1%) and gingiva (21.4%) were the most affected oral sites. Histologically, the tumors exhibited proliferation of spindle cells between vascular clefts and extravasated erythrocytes. Conclusion Oral KS-AIDS was frequent in young black adult males, with severe immunosuppression and high viral load counting, mostly with lesions manifested in the same period of diagnosis of infection by the Human Immunodeficiency Virus (HIV).