Structural and Thermal Studies of PGA/LDPE Microsphere

Low density polyethylene (LDPE) microsphere doped with different amount of polyglycolic acid (PGA) is synthesized by chemical decomposition method. A synthesized microsphere is structurally characterized by X-ray diffraction, FT-IR and scanning electron microscopy. From the data it is observed that, PGA/LDPE microparticles are amorphous having spherical surface with few irregularities. Formation of PGA/LDPE is confirmed by FT-IR. Thermal decomposition of PGA/LDPE microspheres is studied with the help of TGA and DSC and its density was determined by powder bulk method. Antimicrobial activity is also tested for PGA added LDPE microparticals against E.coli and P.acne to check their bioactivity. The rate of drug release by microparticles (PGA/LDPE) was tested for amoxicillin trihydrate.