Relationship between antitumor effect of polysaccharides and biogenic amines in tumor tissues.

Relationship between the host-mediated antitumor effect and biogenic amines was investigated. Histamine and serotonin values in solid tumor of sarcoma 180 were periodically determined by fluorometric method. When treated with the antitumor active polysaccharide (EA5), significantly high histamine values were detected at the end of 2 weeks after tumor transplantation. Although some increase of the histamine value was also found at 2 and 3 weeks by treatment with the antitumor inactive polysaccharide (EA505) and/or cyclic adenosine monophosphate it was not significant in comparison with the remarkable increase in the antitumor active polysaccharide (EA5) treatment. Any remarkable increase of serotonin values in tumor tissues was not found.