Left ventricular diastolic function dysfunction and its related risk factors in older adults: Guangzhou Biobank Cohort Study - CVD

Objective To study left ventricular diastolic function and its risk factors in relatively healthy older people in Guangzhou.Methods A cross-sectional investigation was performed in a random sample,from the Guangzhou Biobank Cohort Study,of 390 individuals aged 50 years or above and without apparent diseases including stroke,myocardial infarction,COPD and cancers.Personal history,blood pressure,fasting glucose and lipids were assessed.Color Doppler ultrasound was used to measure indicators of left ventricular diastolic function,including peak E velocity and peak A velocity of mitral diastolic flow(E) and(A),E/A ratio,the deceleration time of peak E(DT),and isovolumic relaxation time(IVRT).Results ①With increasing age,peak A significantly increased and E/A level significantly decreased(all P0.05).②After adjusting age and sex,A and IVRT increased,while E/A decreased with waist circumference.Moreover,A increased with triglyceride and fasting plasma glucose(all P0.05).③After adjusting age and sex,A was positively associated with systolic and diastolic blood pressure(all P0.05),while E/A was negatively associated with systolic and diastolic blood pressure in tertiles in 310 individuals without antihypertensive medication(all P0.05).④There was a trend of increase in A(P0.05) and decrease in E/A(P0.05) from optimal to normal blood pressure to hypertension.Conclusions Higher blood pressure was an independent risk factor for left ventricular diastolic dysfunction.Even within normal blood pressure level,left ventricular diastolic function may deteriorate with increased blood pressure.