Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake

Abstract A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta™) has proven to be effective in clinical trials for the treatment of depression.