Pengaruh Garcinia Mangostana Terhadap Paparan Bising Yang Dinilai Dari Pemeriksaan Scanning Electron Microscope (SEM) Pada Rattus norvegicus

Noise is one of etiology that may cause hearing loss. Target organ which usually become damage are organ of corti in cochlear. Structural changes that occur are believed to involve oxidation of free radicals. The purpose of this study is to prove the effect of pericarp extract of Garcinia mangostana as an effective antioxidant and secure to prevent the damage to the cochlear organ of corti which may lead to NIHL viewed from its SEM examination. An in vivo laboratory experimental study with post test only group design used Wistar strain of white rats (Rattus norvegicus). The samples were 24 rats divided into 6 groups: 3 groups had aquadest and the others had pericarp extract of Garcinia mangostana for 16 days. In every 8 hours, each groups had exposed by different intensity of noise exposure (25-50 dB, 55-80 dB, and 85-110 dB) for next 8 days continually. All samples were examined for the ultrastructure image of organ corti by SEM. Examination result obtained showed no significant difference (p>0,05) between experiment groups. The oral administration of pericarp extract of Garcinia mangostana at doses 21.6 mg for 16 days per day showed no significant effect in the way to prevent damage of organ corti, especially in 85-110 dB intensity for 8 days (p=0,127). Key Word: Garcinia mangostana, noise, organ of corti Universitas Sumatera Utara