Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes.

Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled 19F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI.