SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

Matthew F. Barber,Eriko Michishita-Kioi,Yuanxin Xi,Luisa Tasselli,Mitomu Kioi,Zarmik Moqtaderi,Ruth I. Tennen,Silvana Paredes,Nicolas L. Young,Kaifu Chen,Kevin Struhl,Benjamin A. Garcia,Or Gozani,Wei Li,Katrin F. Chua

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

2012

Matthew F. Barber
Eriko Michishita-Kioi
Yuanxin Xi
Luisa Tasselli
Mitomu Kioi
Zarmik Moqtaderi
Ruth I. Tennen
Silvana Paredes
Nicolas L. Young
Kaifu Chen
Kevin Struhl
Benjamin A. Garcia
Or Gozani
Wei Li
Katrin F. Chua

SIRT7 is an H3K18Ac-selective deacetylase that has a pivotal role in chromatin regulation, maintenance of cellular transformation programs and tumour formation in vivo.

Keywords:

Cell biology
SIRT7
Acetylation
Sirtuin
Histone
Chromatin
Repressor
Carcinogenesis
Biology
Biochemistry
SIRT3
Transcription factor
Histone deacetylase
Histone H3

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